This is just from my observations, experiences and beliefs training and rescuing dogs, I am not a behaviorist and I'm sure there are books maybe even web sites that would have a way better answer than my off the cuff opinions expressed here.
It is my opinion temperament is the basic building block of a dogs personality and what their initial reaction to the situation is. This characteristic defines if the dog is shy, friendly, dominant, submissive etc. Temperament can be passed down through genetics and molded through early socialization and imprints. Once an imprint sets in it is almost impossible to change. I have seen temperament gradually evolve as dogs mature.
This I believe is the nature of the breed and is purely genetic. These are the inherited traits and drives that breeds are known for. The breed I know are Border Collies As I'm sure you know they are known for their energy, intelligence, herding drive, prey drive and sometimes being snobs around other dogs. Not all border collies have these traits but often they will demonstrate these characteristics but bcs are more prone to these traits. Manifestations of nature in border collies are herding children or "nipping legs/heels" (herding). Drives can get out of control, when herding drive goes to the extreme it becomes prey drive. Example, border collies 6 out of 10 will be high energy, intelligent and have the desire to keep children and other animals grouped in tight packs. Manifestations of nature in border collies are herding children or "nipping legs/heels" (herding). Example, border collies 6 out of 10 will be high energy, intelligent and have the desire to keep children and other animals grouped in tight packs.
One thing left out of the question are drives, drives are an important aspect of breed nature especially when we talk about working dogs. Working dogs were bred over centuries to maximize working drives like herding and protection work. Drives can get out of control, when herding drive goes to the extreme it becomes prey drive. This is one of the top reasons border collie end up in shelters and rescues.
Behavior are manifestations of temperament, nature, drives, nurture (training and care) and environment. Behavior is what people see and can work to modify and redirect.
I would say nurturing, training and environment are one of the most important aspects of developing a well rounded dog, I would never write off a dog just because of their temperament, nature or drives. My personal dog was a neurotically shy dog when he came to my house, he is a 40lb American Eskimo/Golden Retriever mix, it took me 2 months of him hiding under my bed before I was able to actually work with him. beyond his looks he was pretty much unadoptable, his temperament gave him a strong probability of becoming a fear biter if he did not go to the right handler. After hundreds of hours of socialization, desensitization, trust building and training; he's become a very well rounded dog that approaches strangers and has developed relationships with people besides me. He is public off leash trained and enjoys leaving the house with pride and confidence now. After 2 years his shy temperament often still shows but he has come so far you wouldn't recognize him as the same dog.
In conclusion, I am a true believer that every one of these topics are interdependent and come together to make the whole dogs. Nature and temperament feed off eachother and occasionally work to exaggerate nature creating negative behaviors, combined with other issues can become very bad... Example, an untrained overly assertive, dominant dog who has no avenue of burning off excess energy combined with a strong herding drive with no socialization with children often will develop herding/prey drive with children who are frantically running around, this is a recipe for a bite.